Persistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models
نویسندگان
چکیده
منابع مشابه
P 145: A Review of Animal Models of Absence Epilepsy
The most common type of childhood-onset epilepsy syndrome is childhood absence epilepsy (CAE) with well-defined electro clinical features but unknown pathological basis. The incidence of absence epilepsy is about 2 and 8 out of every 100 000 children up to the age of 16, and the prevalence is 2 and 10% of children with any form of epilepsy. Children with CAE suffer from high rate of pretreatmen...
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Background: Absence epilepsy is a brief non-convulsive seizure that associated with sudden abrupt in consciousness. Because of the unpredictable occurrence of absence seizures and ethic limitation of human investigation on the pathogenesis and drug assessment led to the tendency to animal models. The aim of this paper is reviewing the advantages and disadvantages of several animal models of non...
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Neurogenesis in the hippocampal dentate gyrus persists throughout life and is increased by seizures. The dentate granule cell (DGC) layer is often abnormal in human and experimental temporal lobe epilepsy, with dispersion of the layer and the appearance of ectopic granule neurons in the hilus. We tested the hypothesis that these abnormalities result from aberrant DGC neurogenesis after seizure-...
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The level of activity of many animals including humans rises and falls with a period of ~ 24 hours. The intrinsic biological oscillator that gives rise to this circadian oscillation is driven by a molecular feedback loop with an approximately 24 hour cycle period and is influenced by the environment, most notably the light:dark cycle. In addition to the circadian oscillations, behavior of many ...
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Phase-amplitude coupling (PAC), the phenomenon where the amplitude of a high frequency oscillation is modulated by the phase of a lower frequency oscillation, is attracting an increasing interest in the neuroscience community due to its potential relevance for understanding healthy and pathological information processing in the brain. PAC is a diverse phenomenon, having been experimentally dete...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2017
ISSN: 0022-3751
DOI: 10.1113/jp274696